probe compounds

ML179 is a potent and selective inverse agonist of liver receptor homolog-1 (LRH1, NR5A2) with IC50 of 320 nM.

Flavonol (3-Hydroxyflavone) is a member of the class of compounds known as flavonols. 3-hydroxyflavone can be found in a number of food items such as brassicas, pomegranate, red raspberry, and fenugreek. 3-hydroxyflavone is a chemical compound. It is the backbone of all flavonols, a type of flavonoid. It serves as a model molecule as it possesses an excited-state intramolecular proton transfer (ESIPT) effect to serve as a fluorescent probe to study membranes for example or intermembrane proteins.

Cyclohexylacetic acid is an important aliphatic carboxylic acid organic reagent. Cyclohexylacetic acid serves as a key intermediate in organic synthesis for the production of antiepileptic drugs, anti-inflammatory drugs, herbicides, and other compounds. Cyclohexylacetic acid can also be used as a culture medium additive, a buffer component, or a metabolic probe.

VZMC013 is a potent chemical probe targeting the MOR-CCR5 heterodimer, effectively inhibiting HIV-1 entry exacerbated by opioid compounds. It exhibits nanomolar binding affinity to both MOR and CCR5, inhibits CCL5-activated calcium mobilization, and significantly enhances anti-HIV-1BaL activity compared to previously reported bivalent ligands. In TZM-bl cells co-expressing CCR5 and MOR, VZMC013 demonstrates greater inhibition of viral infection than in cells expressing only CCR5. Additionally, VZMC013 blocks HIV-1 entry into peripheral blood mononuclear cells (PBMC) in a concentration-dependent manner and more effectively inhibits opioid-accelerated HIV-1 entry in phytohemagglutinin-activated PBMC than in opioid-free environments.

2-(3-methyl-1H-1,2,4-triazol-5-yl)aniline is a high-purity biochemical reagent that can be used as a specific probe to assist in the analysis of the biochemical mechanism of nitrogen-containing heterocyclic compounds for biochemical experiments and drug synthesis research.

Trisulfo-Cy3 Methyltetrazine is a click chemistry reagent featuring a methyltetrazine group. This methyltetrazine-activated Cy3 probe forms stable covalent bonds with compounds containing TCO through an inverse electron-demand Diels-Alder reaction, without the need for a copper catalyst or elevated temperatures.

N3-TFBA-O2Oc is a photochemical probe comprising azide and aryl groups. This type of azidoaryl compound serves as a classical precursor to nitro compounds and has been utilized by Fleet et al as a versatile photophore for probing biological receptors. Specifically, N3-TFBA-O2Oc functions as a photo-crosslinker (λmax=258 nm) in studies involving estrogen receptors and for direct surface coating of carbon and organic polymers. Additionally, as a click chemistry reagent, N3-TFBA-O2Oc contains an azide group that reacts with molecules featuring an alkyne group through a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc). It can also engage in strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules that possess DBCO or BCN groups.

trans-4-(Trifluoromethyl)cinnamic acid belongs to the cinnamic acid class of compounds that can be isolated from cinnamon bark and exhibits a 74.8% inhibitory effect on protein tyrosine phosphatase.

6-Methoxyquinoline is a quinoline derivative commonly used as an intermediate in antimicrobial drugs, widely applied in biochemical experiments and drug synthesis research.

Photobiotin (acetate) is a biological probe employed in the investigation of protein interactions and enzymatic reactions among various biochemical processes. This molecule, equipped with a photosensitive group, utilizes photochemical cross-linking technology to bind with specific target molecules like proteins and nucleic acids, enabling their labeling and detection. During the photosensitive cross-linking, Photobiotin (acetate) engages in covalent bonding, forming stable compounds. Furthermore, its significant biocompatibility and bioactivity make it extensively applicable in biomedical research areas such as enzymology, proteomics, and Western blotting. As a click chemistry reagent, Photobiotin (acetate) contains an Azide group, facilitating copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with Alkyne-containing molecules. It can also partake in strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules containing DBCO or BCN groups.