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By Target- BTK
- TLR(1)
- Others(1)
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Results for "
poseltinib
" in TargetMol Product Catalog- Inhibitors & Agonists1
Poseltinib
LY3337641, LY 3337641, HM71224, HM 71224
T44131353552-97-2
Poseltinib is an orally active, selective, and irreversible inhibitor of Bruton's tyrosine kinase (BTK), with an IC50 value of 1.95 nM. Poseltinib demonstrates 0.3-, 2.3-, and 2.4-fold higher selectivity for BTK over BMX, TEC, and TXK, respectively. Poseltinib covalently binds to cysteine 481 in BTK’s active site, thereby inhibiting BCR-, FcR-, and TLR-mediated signaling pathways.
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