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By Target- Microtubule Associated
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Results for "
plinabulin
" in TargetMol Product Catalog- Inhibitors & Agonists3
- Isotope Products1
Plinabulin
NPI-2358
T2511714272-27-2
Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targets and binds to the colchicine-binding site of tubulin, thereby interrupting equilibrium of microtubule dynamics. This disrupts mitotic spindle assembly leading to cell cycle arrest at M phase and blockage of cell division.
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MBRI-001
NPI-2358-d, plinabulin-d, MBRI 001, MBRI001
T279822054938-28-0
MBRI-001 is a deuterium-substituted plinabulin derivative and a potent anti-cancer agent with better pharmacokinetic characteristics tand lower toxicity.
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Piperafizine A
T38699130603-59-7
Piperafizine A is isolated from Streptoverticillium aspergilloides and potentiates vincristine antitumor potency.
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