phomopsin a

Phomopsin A, a cyclic hexapeptide mycotoxin, is isolated from the fungus Phomopsis leptostomiformis.

Phomopsin D is a mycotoxin and a derivative of Phomopsin A. Phomopsin A, a cyclic hexapeptide mycotoxin, is isolated from the fungus [Phomopsis leptostomiformis]. It acts as a non-competitive inhibitor of the binding of radiolabeled vinblastine to tubulin.

Phomopsin B (Compound 3) is a hexapeptide that acts as a microtubule depolymerizing agent and can be isolated from the fungus Phomopsis Leptostromiformis. It exhibits anti-mitotic activity and is useful for cancer research.

Phomopsinamine is an inhibitor of microtubule polymerization and a derivative of phomopsin A .1It inhibits the rate and extent of polymerization of tubulin isolated from ovine brain (IC50s = 0.53 and 0.59 μM, respectively). 1.Lacey, E., Edgar, J.A., and Culvenor, C.C.Interaction of phomopsin A and related compounds with purified sheep brain tubulinBiochem. Pharmacol.36(13)2133-2138(1987)