phenylacetyl-coenzyme a

Phenylacetyl-coenzyme A (CoA) is a key intermediate in aerobic catabolism of phenylacetate in bacteria such asPseudomonas, when cultured in minimal media using phenylacetate as the sole carbon source.1It is a precursor in the synthesis of the antibiotic penicillin G found in industrial strains ofP. chrysogenum. Phenylacetyl-CoA also acts as an effector molecule of the TetR family transcriptional repressor PaaR inT. thermophilusand the GntR family transcriptional regulator PaaX inE. coliandPseudomonas, binding to each protein to induce derepression of various genes.2

Phenylacetyl Coenzyme A (Phenylacetyl Coenzyme A) tetrasodium serves as an effector molecule for the TetR family transcription repressor protein PaaR. It alters the conformation of PaaR, facilitating its dissociation from DNA and initiating transcription. This compound holds potential for use in the study of microbial metabolism.