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phenoxybenzamine

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  • Inhibitors & Agonists
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    TargetMol | Inhibitors_Agonists
Phenoxybenzamine
NSC-37448,A688,NSC 37448,NSC37448,A-688
T1158L59-96-1
Phenoxybenzamine is an α-1 adrenergic receptor antagonist. Phenoxybenzamine may exert a neuroprotective effect by reducing neuroinflammation after traumatic brain injury.
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Phenoxybenzamine hydrochloride
NCI-c01661, NSC 37448, Phenoxybenzamine HCl
T115863-92-3
Phenoxybenzamine hydrochloride (NCI-c01661) is the hydrochloride salt form of phenoxybenzamine, a synthetic, dibenzamine alpha-adrenergic antagonist with antihypertensive and vasodilatory properties. Phenoxybenzamine non-selectively and irreversibly blocks the postsynaptic alpha-adrenergic receptor in smooth muscle, thereby preventing vasoconstriction, relieving vasospasms, and decreasing peripheral resistance. Reflex tachycardia may occur and may be enhanced by blockade of alpha-2 receptors which enhances norepinephrine release. Phenoxybenzamine is reasonably anticipated to be a human carcinogen.
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