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pharmacodynamic model

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  • Inhibitors & Agonists
    2
    TargetMol | Inhibitors_Agonists
TCS 1102
DORA-1
T2710916141-36-1
TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2 3 nM for OX2 1 receptors).
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IWP-051
IWP051
T322421354041-91-0
IWP-051 is a potent, orally active sGC stimulator (EC50 = 290nM). IWP-051 showed >99% plasma protein binding, high metabolic stability, high permeability, and no efflux in a Caco-2 model of intestinal absorption. IWP-051 achieves good alignment of pote
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8-10 weeks
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