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Results for "
pf6689840
" in TargetMol Product Catalog- Inhibitors & Agonists1
PF-6689840
T676931799790-53-6In house
PF-6689840 is a potent and selective Type II PTK6 Brk inhibitor with IC50 of 54 nM in biochemical assays; inhibits PTK6 phosphorylation at Y342 in engineered HET293T cells overexpressing PTK6 WT with IC50 of 0.25 uM; demonstrates superior kinase selectivity compared to the Type I inhibitors; inhibits tumor cell growth, which is independent of PTK6 expression levels in cells.
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