pde5 in 2

PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5 (IC50 of 0.31 nM).

PDE5-IN-8 (compound 2) is an inhibitor of PDEs.

Lodenafil carbonate, a prodrug dimer that delivers Lodenafil in vivo, is an orally active inhibitor of phosphodiesterase type 5 (PDE5), indicated for the treatment of erectile dysfunction (ED)[1][2].

PDE5-IN-10 (compound 4b), a potent phosphodiesterase type 5 (PDE5) inhibitor, exhibits an effective half-maximal inhibitory concentration (IC50) of 20 nM, enhanced in vitro microsomal stability (t 1 2 = 44.6 min), and excellent efficacy in restoring long-term potentiation, making it suitable for Alzheimer's disease (AD) research [1].

N-Desethyl-N-methyl Vardenafil, a potential impurity in commercial vardenafil preparations, functions as a phosphodiesterase 5 (PDE5) inhibitor, similar to its parent compound. With an IC50 value of 2 nM, it exhibits potent inhibitory activity against PDE5.