orexin a (human, rat, mouse) (tfa)

Endogenous agonist at orexin receptors (Ki values are 20 and 38 nM for OX1 and OX2 receptors respectively). Stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions.

Orexin A-13C18,15N3 (human, rat, mouse) ((Hypocretin-1-13C18,15N3 (human, rat, mouse)) TFA) is a compound labeled with 13C and 15N, and it is a form of Orexin A (human, rat, mouse). Orexin A, also known as Hypocretin-1, is a 33 amino acid excitatory neuropeptide involved in various central and peripheral processes. It binds to and activates two G protein-coupled receptors: the Orexin-1 receptor (OX1R) and Orexin-2 receptor (OX2R), playing a crucial role in regulating feeding behavior. Orexin A is also an active molecule with potent antinociceptive and anti-hyperalgesic properties.

Orexin A-13C6,15N (human, rat, mouse) (also known as Hypocretin-1-13C6,15N (human, rat, mouse)) TFA is an isotopically labeled version of Orexin A (human, rat, mouse). This 33-amino acid excitatory neuropeptide is involved in various central and peripheral processes. It binds to and activates two G protein-coupled receptors, the Orexin-1 receptor (OX1R) and the Orexin-2 receptor (OX2R), playing a crucial role in regulating feeding behavior. Additionally, Orexin A (human, rat, mouse) is an effective agent against nociception and hyperalgesia.