ono-po736

Freselestat (ONO-6818) is a potent neutrophil elastase inhibitor that significantly reduces the production of interleukin 8 and C5B-9, thereby decreasing inflammatory mediators during simulated cardiopulmonary bypass.

Freselestat quarterhydrate (ONO-6818 quarterhydrate) is a potent, orally active inhibitor of neutrophil elastase (Ki: 12.2 nM). The quarterhydrate is more than 100-fold less active against other proteases, including trypsin, proteinase 3, pancreatic elastase, thrombin, fibrin, collagenase, histone G, and murine macrophage elastase, and exhibits potent anti-inflammatory effects.