octadecanedioic acid

Octadecanedioic acid is an endogenous metabolite, is a long-chain dicarboxylic acid.

Octadecanedioic acid-d32 is a deuterium-labeled form of Octadecanedioic acid. This compound is an endogenous metabolite and can be utilized in the study of Reye's syndrome.

9-Oxooctadecanedioic acid is an α,ω-dicarboxylic fatty acid monomer found in the suberin of Quercus suber cork. It plays a role in the composition of plant structures.

Paclitaxel octadecanedioate is a prodrug form of paclitaxel that is comprised of paclitaxel conjugated to 1,18-octadecanedioic acid.1 Unlike paclitaxel, it does not promote tubulin polymerization in vitro when used at a concentration of 10 μM. A 5:1 mixture of paclitaxel octadecanedioate:human serum albumin (HSA) is cytotoxic to HT-1080, PANC-1, and HT-29 cells (IC50s = 12, 2.48, and 8.62 nM, respectively). This mixture reduces tumor growth and increases survival in an HT-1080 mouse xenograft model in a dose-dependent manner. |1. Callmann, C.E., Leguyader, C.L.M., Burton, S.T., et al. Antitumor activity of 1,18-octadecanedioic acid-paclitaxel complexed with human serum albumin. J. Am. Chem. Soc. 141(30), 11765-11769 (2019).

18-Oxooctadecanoic acid is a derivative of long-chain fatty acids. It is specifically oxidized by P450BM-3 to form the corresponding α,ω-dicarboxylic acid (1,18-octadecanedioic acid) without undergoing a decarboxylation reaction that would produce an alkene with a carbon chain reduced by one carbon. 18-Oxooctadecanoic acid can be used to study metabolic pathways of long-chain fatty acids with aldehyde groups.