noncytotoxic

Hexa-D-arginine is an inhibitor of furin,blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo.

JAK3-IN-11 (Compound 12) exhibits potent, noncytotoxic, irreversible, orally active JAK3 inhibitory activity (IC50 = 1.7 nM) with an excellent selectivity profile (>588-fold compared to other JAK isoforms), covalently binds to the ATP-binding pocket in JAK3. JAK3-IN-11 strongly inhibits JAK3-dependent signaling and T-cell proliferation which is a promising tool for studying autoimmune diseases [1].

INF39 is a noncytotoxic and irreversible NLRP3 inhibitor.

PNU-145156E (formerly FCE 26644) is a noncytotoxic small molecule that exerts antitumor activity through reversible complex formation with growth and angiogenic factors, thereby inhibiting their ability to induce angiogenesis. PNU-145156E is utilized in research on tumor vascularization, angiogenesis regulation, and the development of anti-angiogenic therapeutic strategies.

PD-128763 is a poly(ADP-ribose) polymerase inhibitor exhibiting radiosensitising effects, enhancing radiation-induced cell killing in X-ray-irradiated Chinese hamster V79 cells.

LIMK1 inhibitor BMS-4 is a compound targeting LIM Kinase (LIMK) 1/2, specifically inhibiting the phosphorylation of its substrate cofilin, while remaining noncytotoxic on A549 cells.