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n desmethyltamoxifen hydrochloride

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  • Inhibitors & Agonists
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N-Desmethyltamoxifen hydrochloride
T1214815917-65-4
N-Desmethyltamoxifen hydrochloride is the primary metabolite of tamoxifen in humans.
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SIM010603
T715761032265-67-0
SIM010603 is a structurally novel, oral, multi-targeted receptor tyrosine kinase inhibitor. SIM010603 inhibited stem cell factor receptor (Kit), vascular endothelial growth factor receptor-2 (VEGFR-2), platelet-derived growth factor receptor-β (PDGFR-β), glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), and Fms-like tyrosine kinase-3 (FLT3) with IC(50) values between 5.0 and 68.1 nmol l. SIM010603 inhibited the phosphorylation of PDGFR-β and VEGFR-2. Moreover, SIM010603 inhibited endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis.
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8-10 weeks
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