mmp9in1

MMP-9-IN-1 is an inhibitor of specific matrix metalloproteinase-9 (MMP-9).

MMP-9-IN-10 (compound 4f) is a selective MMP-9 inhibitor with an IC50 of 5 nM. It is applicable in the study of cancer and inflammation.

MMP-9-IN-11 (compound 77) is a potent MMP-9 inhibitor. It exhibits significant cytotoxic activity against A549 and L929 cell lines, with IC50 values of 4.04 and 13.97 μg/mL, respectively.

MMP-9-IN-12 is an inhibitor of matrix metalloproteinase-9 (MMP-9) with an IC50 value of 6.57 μM. It demonstrates an IC50 of 1.54 μM in HCT-116 cells and can induce apoptosis, reactive oxygen species (ROS) generation, and mitochondrial depolarization. Additionally, MMP-9-IN-12 inhibits cell migration and disrupts cell cycle progression, making it useful for colorectal cancer (CRC) research.