largazole

Largazole is a potent and selective histone deacetylase (HDAC) inhibitor and antiproliferative agent from Symploca.

Largazolethiol, the active form of Largazole, is a potent and selective class I HDAC inhibitor capable of crossing the blood-brain barrier. Largazole thiol exhibits antitumor and neuroprotective properties and is applicable in research on glioblastoma and Alzheimer's disease.

OKI-006, a potent and orally active histone deacetylase (HDAC) inhibitor, stands as a distinctive derivative of the natural product HDAC inhibitor, largazole. By targeting HDACs—key players in epigenomic regulation whose dysfunction often occurs in numerous human cancers—OKI-006 holds promise for cancer research applications [1].