lactate dehydrogenase

D-Lactate dehydrogenase (D-LDH), an oxidoreductase, catalyzes the oxidation of D-lactate to pyruvate leveraging NAD+ or NADP+ as acceptors and acting on the donor CH-OH group. Predominantly found in bacteria and fungi, it is frequently utilized in biochemical research [1].

L-Lactate dehydrogenase (LAD) is an oxidoreductase enzyme in the anaerobic metabolic pathway and the gluconeogenic pathway, and is found in a wide range of tissues in the body.

Lactate Dehydrogenase (LDH), sourced from Chicken Heart (LAD, LD, L-LDH, (S)-Lactate, LDH), serves as a biomaterial or organic compound useful for life science research.

Lactate Dehydrogenase (LDH), derived from Porcine Heart, also known as Lactic Dehydrogenase, serves as a biological material or organic compound utilized in life science research.

Lactate Dehydrogenase1 (LDH-1), derived from human erythrocytes and also known as LDH-1, LD1 isoenzyme, 4H isoenzyme, or Lactic Dehydrogenase, is a biological material or organic compound useful for life science research.

Lactate Dehydrogenase, Bovine Heart belongs to the oxidoreductase family and catalyzes the reversible conversion between lactic acid and pyruvic acid. It is mainly used in life science research, the diagnostic detection of tissue damage, and also serves as an enzymatic marker in relevant experiments and assays.

Lactate Dehydrogenase 4 (LDH-4), Human Liver (LDH-4 isoenzyme, 1H3M isoenzyme, ld4 isoenyzme) is a biological material or organic compound suitable for use in life science research.

Lactate Dehydrogenase 2 (LDH-2), derived from human erythrocytes (LDH-2 (3H1M), LD2), is a biological material or organic compound suitable for use in life sciences research.

L-Lactate Dehydrogenase, bovine muscle, is a redox enzyme that catalyzes the reversible conversion of lactate to pyruvate while simultaneously reducing NAD+ to NADH.

Lactate Dehydrogenase5 (LDH-5), Human Liver (LD-5 Isoenzyme, LDH-5 Isoenzyme, 4M Isoenzyme) is available for use as a biomaterial or organic compound in life science research.

Lactate Dehydrogenase3 (LDH-3), Human Erythrocytes (LDH-3, LD3, LD-3, 2H2M), is a biological material or organic compound suitable for use in life science research.

Nifurtimox (BAY-A-2502) is an antiprotozoal agent (IC50s = 9.91, 12.28, and 10.44 μM against Taluahuén, LQ, and Brener strains of T. cruzi- epimastigotes, respectively).

Isomalt (Palatinitol) is a mixture of 1,6-mannitol glucopyranoside and 1,6-sorbitol glucopyranoside

Glomeratose A, a lactate dehydrogenase inhibitor (LDH), [Compound BBX] is a small molecule that targets enzyme inhibitors (MJBB-_13798), effectively reducing lactate production in cells, thereby influencing metabolic processes and demonstrating potential therapeutic applications in conditions characterized by elevated lactate levels.

hDHODH-IN-1 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor exhibiting anti-inflammatory properties.

LDH-IN-1 is a pyrazole-based human lactate dehydrogenase (LDH) inhibitor(IC50s of 32 and 27 nM for LDHA and LDHB, respectively).

PfDHODH-IN-1, an analogue of the active Leflunomide metabolite, exhibits antimalarial activity.

GSK2837808A is a potent and selective inhibitor of lactate dehydrogenase A (LDHA) with IC50 values of 1.9 nM for LDHA and 14 nM for LDHB.

Galloflavin is a lactate dehydrogenase inhibitor that inhibits the activity of lactate dehydrogenase. Galloflavin inhibits both human LDH isoforms (type A and type B) by preferentially binding to the free enzyme without competing with substrates or cofactors, with Ki values ​​calculated by pyruvate of 5.46 μM (LDH-A) and 15.06 μM (LDH-B).

Tenuifoliside C, isolated from Polygala tenuifolia Willd, is a targeted lactate dehydrogenase inhibitor that significantly inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1[1].

LDHA-IN-4 (AZ33) is an LDHA inhibitor. Binding affinity to 6-His-tagged human LDHA (2 to 322 amino acid residue) expressed in Escherichia coli BL21 (DE3) cells by SPR analysis with an active value of 0.093 μM.

(R)-GNE-140 (GNE-140) is an effective LDHA/LDHB inhibitor (IC50s: 3/5 nM) and is 18-fold more potent than S enantiomer.

1. 3-Dehydrotrametenolic acid can be a potential anticancer agent against H-ras transformed tumor. 2. Dehydrotrametenolic acid is a promising candidate for a new type of insulin-sensitizing drug.

GNE-140 is a potent inhibitor of lactate dehydrogenase A (LDHA). GNE-140 is a racemate mixture of (R)-GNE-140 and (S)-GNE-140.