lactate dehydrogenase

D-Lactate dehydrogenase (D-LDH), an oxidoreductase, catalyzes the oxidation of D-lactate to pyruvate leveraging NAD+ or NADP+ as acceptors and acting on the donor CH-OH group. Predominantly found in bacteria and fungi, it is frequently utilized in biochemical research [1].

L-Lactate dehydrogenase (LAD) is an oxidoreductase enzyme in the anaerobic metabolic pathway and the gluconeogenic pathway, and is found in a wide range of tissues in the body.

Lactate Dehydrogenase (LDH), sourced from Chicken Heart (LAD, LD, L-LDH, (S)-Lactate, LDH), serves as a biomaterial or organic compound useful for life science research.

Lactate Dehydrogenase (LDH), derived from Porcine Heart, also known as Lactic Dehydrogenase, serves as a biological material or organic compound utilized in life science research.

Lactate Dehydrogenase1 (LDH-1), derived from human erythrocytes and also known as LDH-1, LD1 isoenzyme, 4H isoenzyme, or Lactic Dehydrogenase, is a biological material or organic compound useful for life science research.

Lactate Dehydrogenase (LDH), derived from Bovine Heart (also known as LAD, LD, L-LDH, (S)-Lactate: NAD+ oxidoreductase), serves as a biological material or organic compound used in life science research.

Lactate Dehydrogenase 4 (LDH-4), Human Liver (LDH-4 isoenzyme, 1H3M isoenzyme, ld4 isoenyzme) is a biological material or organic compound suitable for use in life science research.

Lactate Dehydrogenase 2 (LDH-2), derived from human erythrocytes (LDH-2 (3H1M), LD2), is a biological material or organic compound suitable for use in life sciences research.

L-Lactate Dehydrogenase, bovine muscle, is a redox enzyme that catalyzes the reversible conversion of lactate to pyruvate while simultaneously reducing NAD+ to NADH.

Lactate Dehydrogenase5 (LDH-5), Human Liver (LD-5 Isoenzyme, LDH-5 Isoenzyme, 4M Isoenzyme) is available for use as a biomaterial or organic compound in life science research.

Lactate Dehydrogenase3 (LDH-3), Human Erythrocytes (LDH-3, LD3, LD-3, 2H2M), is a biological material or organic compound suitable for use in life science research.

Nifurtimox (BAY-A-2502) is an antiprotozoal agent (IC50s = 9.91, 12.28, and 10.44 μM against Taluahuén, LQ, and Brener strains of T. cruzi- epimastigotes, respectively).

Isomalt (Palatinitol) is a mixture of 1,6-mannitol glucopyranoside and 1,6-sorbitol glucopyranoside

Glomeratose A, a lactate dehydrogenase inhibitor (LDH), [Compound BBX] is a small molecule that targets enzyme inhibitors (MJBB-_13798), effectively reducing lactate production in cells, thereby influencing metabolic processes and demonstrating potential therapeutic applications in conditions characterized by elevated lactate levels.

hDHODH-IN-1 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor exhibiting anti-inflammatory properties.

LDH-IN-1 is a pyrazole-based human lactate dehydrogenase (LDH) inhibitor(IC50s of 32 and 27 nM for LDHA and LDHB, respectively).

PfDHODH-IN-1, an analogue of the active Leflunomide metabolite, exhibits antimalarial activity.

GSK2837808A is a potent and selective inhibitor of lactate dehydrogenase A (LDHA) with IC50 values of 1.9 nM for LDHA and 14 nM for LDHB.

Galloflavin is a lactate dehydrogenase inhibitor that inhibits the activity of lactate dehydrogenase. Galloflavin inhibits both human LDH isoforms (type A and type B) by preferentially binding to the free enzyme without competing with substrates or cofactors, with Ki values ​​calculated by pyruvate of 5.46 μM (LDH-A) and 15.06 μM (LDH-B).

Tenuifoliside C, isolated from Polygala tenuifolia Willd, is a targeted lactate dehydrogenase inhibitor that significantly inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1[1].

LDHA-IN-4 (AZ33) is an LDHA inhibitor. Binding affinity to 6-His-tagged human LDHA (2 to 322 amino acid residue) expressed in Escherichia coli BL21 (DE3) cells by SPR analysis with an active value of 0.093 μM.

(R)-GNE-140 (GNE-140) is an effective LDHA/LDHB inhibitor (IC50s: 3/5 nM) and is 18-fold more potent than S enantiomer.

1. 3-Dehydrotrametenolic acid can be a potential anticancer agent against H-ras transformed tumor. 2. Dehydrotrametenolic acid is a promising candidate for a new type of insulin-sensitizing drug.

GNE-140 is a potent inhibitor of lactate dehydrogenase A (LDHA). GNE-140 is a racemate mixture of (R)-GNE-140 and (S)-GNE-140.