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kb-vin

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  • Inhibitors & Agonists
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M2N12
T119292376577-06-7
M2N12 is a potent and highly selective inhibitor of cell division cycle 25C protein phosphatase (Cdc25C, IC50 = 0.09 μM) and also exhibits anti-tumor activity. Additionally, M2N12 shows promising activity against Cdc25A (IC50 = 0.53 μM) and Cdc25B (IC50 = 1.39 μM).
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Garcilatelic acid
TN11159
Garcilatelic acid (Compound 5) is a chemical compound isolated from Garcinia lateriflora. It demonstrates antiproliferative activity against tumor cell lines (A549, MDA-MB-231, MCF-7, KB, and KB-VIN) with IC50 values ranging from 0.5 to 1.3 μM.
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    Isotenulin
    TN917210092-04-3
    Isotenulin inhibits the efflux function of P-glycoprotein (P-gp) by stimulating P-glycoprotein ATPase, helping to overcome multidrug resistance (MDR) in cancer cells. It exhibits cytotoxicity in multidrug-resistant cancer cells KB-vin and in sensitive cancer cells HeLaS3. Additionally, Isotenulin acts synergistically with Paclitaxel, Vinblastine, and Doxorubicin.
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