ist2-1

iST2-1 is a first-in-class ST2 inhibitor active in vivo.

Hexestrol diphosphate sodium is a synthetic ER agonist, microtubule polymerization inhibitor, and potential carcinogen. It induces mitotic arrest, aneuploidy, and DNA adduct formation.

DREADD agonist 21 is a potent agonist of human muscarinic acetylcholine M3 receptors (EC50=1.7 nM).

DREADD agonist 21 dihydrochloride is a potent agonist of human muscarinic acetylcholine M3 receptors (hM3Dq) with an EC50 of 1.7 nM [1].

GLP-1R agonist 21 (Compound I-134) is an agonist of the glucagon-like peptide-1 receptor (GLP-1 receptor) with an EC50 of 0.0104 nM.

TLR7 agonist21 (Compound 27B) is a selective activator of Toll-like receptor 7 (TLR7), with an EC50 of 17.53 nM for human TLR7 and 41.7 nM for mouse TLR7. It induces the secretion of pro-inflammatory cytokines, including IL-6, TNF-α, IFN-α1, and IL-4. Acting as a vaccine adjuvant, TLR7 agonist21 enhances IgG and IgA levels, offering protection for mice against influenza virus infection.

STING agonist-21 (compound 1), possessing an EC 50 of 592.8 nM, functions as a STING agonist. It is applicable in cancer research [1].