hc-3

HC-3 inhibits ChoK by binding at the conserved hydrophobic groove on the C-terminal lobe.

Pivalopril, a novel orally active angiotensin-converting enzyme inhibitor, acts by blocking the conversion of angiotensin I to angiotensin II.

L321-NH-C3-PEG3-C1-NH2 is a conjugation of the E3 ligase ligand and linker found in BRD4 PROTAC L134.

Boc-NH-C3-O-Ph(NO2)-methylester-O-pyrrolidine-2,5-dione is a linker for PROTACBRD4 Degrader-26, and it is utilized in the synthesis of PROTACs.

Thalidomide-NH-C3-O-Ph(NO2)-methylester-O-pyrrolidine-2,5-dione is a conjugate of a linker and an E3 ligase ligand, utilized in synthesizing PROTACBRD4 Degrader-26.

COOH-C3-COGN-C7-COOH is a PEG-type PROTAC linker utilized for synthesizing PROTAC Degrader ARM165.

AGI-5198 (IDH-C35) is a potent and selective inhibitor of IDH1 R132H and R132C mutants, with IC50 values of 0.07 μM and 0.16 μM, respectively.

Thalidomide-CH2CONH-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based CRBN ligand and linker used in PROTAC technology.

IHC3 is a competitive and reversible monoamine oxidase B (MAO-B) inhibitor with an IC50 of 1.672 μM, targeting Cys172 within the enzyme's active site, used in the study of neurological diseases [1].

HO-CONH-C3-PEG3-NH2 is a linker used in the synthesis of the PROTAC degrader 22-SLF.

Myhc-α(334–352) is a sequence fragment comprised of amino acid residues 334 to 352 of the myocardial myosin heavy chain α (MYHC-α). It serves as an immunodominant epitope capable of inducing an autoimmune response in A/J mice, which leads to the development of myocarditis. Myhc-α(334–352) is utilized in research on the autoimmune pathways involved in myocarditis and dilated cardiomyopathy.

HC-056456 (3,4-Bis(2-thienoyl)-1,2,5-oxadiazole-N-oxide) is a CatSper channel modulator.

TAT-Gap19 TFA, a Cx mimetic peptide and specific connexin43 hemichannel (Cx43 HC) inhibitor, does not inhibit corresponding Cx43 gap junction channels (GJCs). It crosses the blood-brain barrier and has shown efficacy in alleviating liver fibrosis in mice [1] [2] [3].