harringtonine

Harringtonine is a naturally occurring alkaloid that inhibits DNA synthesis and protein synthesis and strongly kills S-phase cells. Harringtonine has antitumor and antiviral activities.

Homoharringtonine (HHT) is a natural alkaloid that inhibits the translation of proteins and is cytotoxic. Homoharringtonine acts on the ribosomes of tumor cells to inhibit the elongation step of protein translation, thereby inhibiting protein synthesis, and has antitumor activity.

Isoharringtonine, a natural alkaloid extracted from Cephalotaxus koreana Nakai, exhibits potent anticancer properties, including the inhibition of cancer cell proliferation and migration, along with the induction of apoptosis. It holds potential for cancer research applications [1] [2].

5′-Des-O-methylharringtonine, a natural product, can be isolated from Cephalotaxus harringtonia [1].