h 8 (hydrochloride)

(S)-2-(2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-yl)ethanamine (Despropionyl ramelteon) hydrochloride is an intermediate used in the synthesis of various active compounds.

1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-ethanamine hydrochloride is a pharmaceutical intermediate used in the synthesis of various active compounds.

H-8 hydrochloride is a reversible and ATP-competitive PKA inhibitor. It can be used to study metabolic diseases.

BI-9627 hydrochloride is a highly potent Na⁺/H⁺ exchanger 1 (NHE1) inhibitor. In intracellular pH recovery assays and human platelet swelling assays, its IC₅₀ values are 6 nM and 31 nM, respectively. It shows more than 30-fold selectivity over NHE2 and has no significant inhibitory effect on NHE3. BI-9627 hydrochloride can reduce the autophagy level of HTR-8/SVneo cells, significantly decrease the intracellular pH of human sperm, partially reverse the effect of DMA, and prolong the Ca²⁺ recovery time in KO hiPSC-CMs. BI-9627 hydrochloride has a low risk of drug-drug interactions, exhibits favorable pharmacokinetic properties in rats and dogs, and demonstrates potent activity in an ex vivo heart model of ischemia-reperfusion injury.

H-L-Phe(4-NH-Poc)-OH (hydrochloride) is a chemical reagent utilized in the modification of phenylalanine or tyrosine analogues in protein and peptide biosynthesis. It contains an alkyne group, facilitating its role in copper-catalyzed azide-alkyne cycloaddition (CuAAC) with molecules that have azide groups. Commonly abbreviated as Poc or Pryoc, this compound acts as both a conventional click conjugation alkyne component and can be combined with tetrazine linkers in copper-free Diels-Alder type click reactions. Additionally, H-L-Phe(4-NH-Poc)-OH serves as a specialized protective group for amines, hydroxyl, and ester groups. Stable under neat trifluoroacetic acid (TFA), degradation occurs at room temperature using TFA:DCM with Co2(CO)8. Deprotection involving other transition metals such as palladium has also been reported.