gedunin

Gedunin is an important limonoid present in several genera of the Meliaceae family, mainly in seeds. Gedunin is an Hsp90 inhibitor, and inhibits ovarian cancer cell proliferation.

Deacetylgedunin is a limonoid that is the 7-deacetyl derivative of gedunin. It has been isolated from Azadirachta indica.

3-α- acetoxydihydrodeoxygeduin (3α DOG)is a kind of partial agonist GPR56.

7-Oxogedunin (Compound 7DG; Compound 16) is a small molecule that protects macrophages from pyroptosis induced by anthrax lethal toxin (LT) by targeting protein kinase R (PKR). By inhibiting the kinase-independent functions of PKR, 7-Oxogedunin effectively suppresses the assembly of various inflammasomes (NLRP1 and NLRP3) and the activation of caspase-1. It also exhibits growth inhibitory activity against European corn borer larvae. 7-Oxogedunin is used in research focusing on LT toxicity inhibition and insecticidal studies.