gadd45β/mkk7

MKK7-COV-9 is a selective and potent covalent inhibitor of MKK7 with inhibitory effects on MKK7-induced protein-protein interactions.MKK7-COV-9 interrupts the activation of primary B-cells in response to LPS.MKK7-COV-9 shows low cytotoxicity at high concentrations.

SP 600125, negative control is a methylated analog of SP 600125 and can be used as a negative control for SP 600125. SP 600125, negative control inhibits DTP3 and GADD45β MKK7 (growth arrest and DNA damage-inducible β mediator-activated protein kinase kinase kinase 7) and is capable of restoring activation.The IC50s of SP 600125, negative control against JNK2 and JNK3 were 18 and 24 μM, respectively.

DTP3 is a selective MKK7 GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.

DTP3 TFA (1809784-29-9 free base) (DTP3 TFA) is a potent and selective GADD45β MKK7 (growth arrest and DNA-damage-inducible β mitogen-activated protein kinase kinase 7) inhibitor.