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By Target- Apoptosis
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Results for "
flavokawain b
" in TargetMol Product Catalog- Inhibitors & Agonists2
- Natural Products1
Flavokawain B
Flavokavain B, Flavokawin B, 2'-Hydroxy-4',6'-Dimethoxychalcone
T6S07351775-97-9
1. Flavokawain B (Flavokavain B) has potent anti-inflammatory activity, can significantly inhibit production of NO and PGE2 in LPS-induced RAW 264.7 cells. 2. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK NF-κB and MAPK signaling pathways. 3. Flavokawain B induces apoptosis, has the potential usefulness of FKB for prevention and treatment of hormone-refractory prostate cancer in an adjuvant setting. 4. Flavokawain B acts through ROS generation and GADD153 up-regulation to regulate the expression of Bcl-2 family members, thereby inducing mitochondrial dysfunction and apoptosis in HCT116 cells.
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