filanesib

Filanesib (ARRY 520) is a selective inhibitor of kinesin spindle protein (KSP, IC50 = 6 nM) with potent anti-proliferative activity.

Filanesib (ARRY-520) targets the kinesin spindle protein (KSP) with potential antineoplastic activity. ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during

(R)-Filanesib (ARRY-520) is a synthetic kinesin spindle protein (KSP) inhibitor with an IC₅₀ of approximately 6 nM. It inhibits KSP-mediated spindle formation, thereby inducing mitotic arrest and suppressing cell proliferation.