ethoxyresorufin-o-deethylase (erod)

Diacetazotol (Diacetotoluide) has activity against dioxin-induced ethoxyisochromamide-O-deethylase (EROD,IC50 = 75±4 nM).

Octachlorodibenzo-p-dioxin (OCDD) is an environmental contaminant with no acute toxicity when administered. In rats, the systemic elimination half-life of Octachlorodibenzo-p-dioxin (50 μg kg intravenously or 50-5000 μg kg orally) is 3-5 months. It can accumulate and concentrate in the liver and adipose tissue after low-dose, repeated exposure. Repeated dosing of Octachlorodibenzo-p-dioxin leads to increased activity of 7-ethoxyresorufin-O-deethylase (7-EROD) and elevated total cytochrome P-450 levels.

2,3,4,6,7,8-Hexachlorodibenzofuran (2,3,4,6,7,8-HxCDF) is a type of polychlorinated dibenzofuran (PCDF). It induces the expression of aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-o-deethylase (EROD) genes in H-4-II-E rat hepatoma cells, with EC50 values of 0.687 and 0.575 nM, respectively.

1,2,3,4,7,8-Hexachlorodibenzofuran (1,2,3,4,7,8-HxCDF) enhances the expression of CYP1A1, CYP1B1, and aryl hydrocarbon receptor repressor (AhRR) genes in human peripheral blood lymphocytes (PBL). It can activate ethoxyresorufin-O-deethylase (EROD), with a BMR20TCDD within the range of 0.115-0.143 nM, corresponding to 20% of the maximum response induced by TCDD.

1,2,3,4,7,8,9-Heptachlorodibenzofuran (1,2,3,4,7,8,9-HpCDF) is a chemical compound known for inducing the expression of CYP1A1 and CYP1B1 genes in human peripheral blood lymphocytes, while also enhancing the expression of the aromatic hydrocarbon receptor repressor (AhRR). In isolated human peripheral blood lymphocytes, it boosts ethoxyresorufin-O-deethylase (EROD) activity—a marker for CYP1A1 activity—in a concentration-dependent manner. Additionally, 1,2,3,4,7,8,9-HpCDF exhibits immunosuppressive properties, reducing the number of plaque-forming cells in mouse spleens and increasing aromatic hydrocarbon hydroxylase (AHH) activity in the liver microsomes of mice injected with sheep red blood cells. This compound is pertinent to research in the fields of immunology, metabolic diseases, and environmental toxicology.

1,2,3,6,7,8-Hexachlorodibenzofuran (1,2,3,6,7,8-HxCDF) is a type of polychlorinated dibenzofuran (PCDF). It promotes the expression of aryl hydrocarbon hydroxylase (AHH) and ethoxyresorufin-O-deethylase (EROD) genes in H-4-II-E rat hepatoma cells with EC50 values of 1.47 and 1.24 nM, respectively. 1,2,3,6,7,8-HxCDF also reduces rat body weight, causes thymic atrophy, and induces the expression of cytochrome P450 (CYP) subtype CYP1A1 and 4-chlorobiphenyl hydroxylase genes with EC50 values of 3.2, 0.9, 0.35, and 0.21 µmol kg.