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(2)
By Target- TGF-beta/Smad
- ALK(1)
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Results for "
e616452
" in TargetMol Product Catalog.- Inhibitors & Agonists2
- Isotope Products1
RepSox
Cited
SJN 2511, E-616452, ALK5 Inhibitor II
T6337446859-33-2
RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM). RepSox induces adipogenesis in MEFs cells.
- $30
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QTY
CitedRepSox-d5
SJN 2511-d5, E-616452-d5
TMIT-0292
RepSox-d5 (E-616452-d5) is a deuterium-labeled form of RepSox. RepSox (E-616452) acts as a potent and selective inhibitor of the transforming growth factor-β receptor I/activin-like kinase 5 (TGF-β-RI/ALK5), effectively inhibiting ALK5 autophosphorylation with an IC50 of 4 nM. It is utilized in the study of obesity and related metabolic disorders, such as type 2 diabetes.
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