e2012

E2012 is a γ-secretase modulator (GSM). E2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid β-42, and induces cataract following repeated doses in the rat.

Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signalling pathway. It possesses neuroprotective activity.

Reboxetine mesylate (FCE20124 mesylate) is a norepinephrine reuptake inhibitor with a Ki of 8.2 nM.

(R,R)-Reboxetine mesylate, an antidepressant agent, exhibits high bioavailability and is the (R,R) enantiomer of Reboxetine, a selective noradrenaline reuptake inhibitor. Contrasting its counterpart, the (S,S) enantiomer, this compound demonstrates low affinity for alpha-adrenergic and muscarinic receptors, alongside low toxicity in animals.