e 616452

RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM). RepSox induces adipogenesis in MEFs cells.

RepSox-d5 (E-616452-d5) is a deuterium-labeled form of RepSox. RepSox (E-616452) acts as a potent and selective inhibitor of the transforming growth factor-β receptor I/activin-like kinase 5 (TGF-β-RI/ALK5), effectively inhibiting ALK5 autophosphorylation with an IC50 of 4 nM. It is utilized in the study of obesity and related metabolic disorders, such as type 2 diabetes.

Tranylcypromine (2-PCPA) hydrochloride (SKF-385 HCl), a Monoamine Oxidase inhibitor, is effective in the treatment of major depression, dysthymic disorder, and atypical depression.

3-Deazaneplanocin A (DZNep) is a dual inhibitor of histone methyltransferase (EZH2) and S-adenosylhomocysteine hydrolase (AHCY) with antipoxidative activity that inhibits hepatic, renal, peritoneal, and airway fibrosis by inducing proteasomal degradation of its targets and reducing toxicity in animal models.