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By Target- DNA Alkylation
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Results for "
dlk-in-1
" in TargetMol Product Catalog- Inhibitors & Agonists2
- Recombinant Protein1
DLK-IN-1
T110561620574-24-4
DLK-IN-1 is a selective oral active inhibitor of bisleucine zipper kinase (DLK, MAP3K12) with Ki of 3 nM. DLK-IN-1 is active in the Alzheimer's disease model, retains excellent CNS permeability, and after multiple days of administration, its concentration
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GDC-0134
RG-6000, RG6000, RG 6000, GDC0134, GDC 0134
T2020431637394-01-4
GDC-0134, a dual leucine zipper kinase (DLK) inhibitor, exhibits brain penetration properties. It inhibits DLK to prevent neuronal degeneration and block JNK activation, potentially treating amyotrophic lateral sclerosis (ALS). It has been assessed in a phase 1 study aimed at treating ALS patients.
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