dextran sulfate sodium salt (mw 4500 5500)

Dextran sulfate sodium salt (MW 5000) can inhibit human immunodeficiency virus (HIV) replication by preventing viral adsorption to host cells and primarily induces inflammation in the colon. Its sulfate groups confer a high negative charge that disrupts the integrity of the intestinal mucosal barrier, leading to barrier damage, macrophage dysfunction, and microbiota imbalance. It is commonly used to induce inflammatory bowel disease (IBD) models.