dbco-peg-4-alkyne

DBCO-PEG4-alkyne is a four-unit PEG linker with non-cleavable properties, specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1].

Methyltetrazine-PEG4-hydrazone-DBCO, a cleavable 4-unit PEG ADC linker, serves as a click chemistry reagent in the synthesis of antibody-drug conjugates (ADCs) [1]. This compound features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-bearing molecules. It also includes a Tetrazine group capable of engaging in an inverse electron demand Diels-Alder reaction (iEDDA) with TCO-bearing molecules.

NH2-PEG4-hydrazone-DBCO serves as a cleavable 4-unit PEG ADC linker employed in the creation of antibody-drug conjugates (ADCs) [1]. This click chemistry reagent features a DBCO group capable of engaging in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules bearing Azide groups.

N,N-Bis(PEG2-N3)-N-amido-PEG2-thiol serves as a cleavable 4 unit PEG ADC linker in the preparation of antibody-drug conjugates (ADCs) [1]. This compound functions as a click chemistry reagent, equipped with an Azide group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-bearing molecules. Additionally, it is capable of engaging in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that contain DBCO or BCN groups.

DBCO-PEG4-HyNic, a cleavable 4-unit PEG ADC linker, is used in the synthesis of antibody-drug conjugates (ADCs) [1]. As a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

DBCO-PEG4-Propionic-Val-Cit-PAB is a click chemistry reagent and a cleavable 4-unit PEG ADC linker that incorporates a DBCO group. This group enables the compound to engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-bearing molecules. It is primarily utilized in the creation of antibody-drug conjugates (ADCs) [1].

N3-PEG4-amido-Lys(Fmoc)-acid is a 4 unit PEG ADC linker utilized in the production of antibody-drug conjugates (ADCs) [1]. This compound, functioning as a click chemistry reagent, is equipped with an Azide group that enables it to partake in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Alkyne group-bearing molecules. Additionally, it is capable of engaging in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Fmoc-NH-Azide-PEG4-L-Lysine-PFP ester serves as a cleavable 4-unit PEG-based ADC linker in the formulation of antibody-drug conjugates (ADCs) [1]. This compound acts as a click chemistry agent featuring an Azide group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-bearing molecules. Additionally, it facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules equipped with DBCO or BCN groups.

4-Arm-PEG-Azide (MW 400) (4-Arm-PEG-N3 (MW 400)) is a PEG derivative composed of PEG units and an azide group. It contains an azide functional group capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that have alkyne groups. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

4-Arm-PEG-Azide (MW 1000) (4-Arm-PEG-N3 (MW 1000)) is a PEG derivative composed of PEG units and azide groups. It contains azide groups that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-containing molecules. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

4-Arm-PEG-Azide (MW .400) (4-Arm-PEG-N3 (MW .400)) is a PEG derivative composed of PEG units and azide groups. The azide groups enable copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with molecules containing alkyne groups. Additionally, it can undergo strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules that have DBCO or BCN groups.

4-Arm-PEG-Azide (MW 600) [4-Arm-PEG-N3 (MW 600)] is a PEG derivative composed of polyethylene glycol (PEG) units and azide groups. The azide group in this compound can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) with alkyne-containing molecules. It can also undergo strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Azide-PEG4-Desthiobiotin is a PEG derivative composed of desthiobiotin, four PEG units, and an azide group (azide). Biotin forms a stable non-covalent complex with Streptavidin. The azide group can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules that have DBCO or BCN groups.

4-Arm-PEG-Azide (MW 2000) [4-Arm-PEG-N3 (MW 2000)] is a PEG derivative made up of PEG units and azide groups. This compound features azide groups that can engage in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with molecules containing alkyne groups. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules that have DBCO or BCN groups.