dbco peg4 pfp ester

DBCO-PEG4-PFP ester is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Fmoc-NH-Azide-PEG4-L-Lysine-PFP ester serves as a cleavable 4-unit PEG-based ADC linker in the formulation of antibody-drug conjugates (ADCs) [1]. This compound acts as a click chemistry agent featuring an Azide group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-bearing molecules. Additionally, it facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules equipped with DBCO or BCN groups.