compound 48/80

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of N-methyl-p-methoxyphenethylamine and formaldehyde produced via a condensation reaction. It acts as a mast cell degranulator and histamine releaser and inhibits phosphatidylinositol-specific phospholipase C activity in human platelets.

S-777469 is a selective, orally active agonist of the cannabinoid type 2 receptor (CB2) (Ki: 36 nM). s-777469 significantly inhibited compound 48 80-induced scratching behaviour in mice in a dose-dependent manner. s-777469 excites CB2, inhibits pruritic signalling and shows an anti-pruritic effect.

Escin IIB, a natural saponin compound isolated from the seeds of horse chestnut (Aesculus hippocastanum L.), exhibits biologically positive effects on acute inflammation in animal models. Escin IIB has also demonstrated strong gastroprotective properties by significantly reducing ethanol-induced gastric mucosal lesions, highlighting its potential application in the study of anti-inflammatory mechanisms and gastric mucosal defense pathways in preclinical research.

Confluentin has antimicrobial activity against the gram-positive bacteria.Confluentin significantly inhibits compound 48/80-induced histamine release from rat peritoneal mast cells. Confluentin also shows weak cytotoxicity against four human tumor cell li

Tripeptide substance P (SP) antagonist (IC50 = 90 μM). Also inhibits binding of SP to Mas-related GPCR (MRGPR) X2. Inhibits SP-induced IgE-independent degranulation of mast cells in vitro. Inhibits compound 48/80-induced MRGPRX2 activation and scratching