choline kinase-a inhibitor

Frenolicin is a selective inhibitor of Prx1 and Grx3 through covalent modification of active-site cysteines.

V-11-0711 HCl is a selective and highly effective choline kinase α (ChoKα) inhibitor that inhibits the catalytic activity of Chk.

MN58b is a selective inhibitor of choline kinase α (CHKα).

ACG548B (compound 24) is a selective dual inhibitor of AChE and BChE with IC₅₀ values of 1.78 and 0.496 μM, respectively, and can be used in research on myasthenia gravis and neurological disorders.

CK37 regulates the biological activity of Choline Kinase-α. CK37 is a small-molecule inhibitor primarily utilized for phosphorylation and dephosphorylation research applications. CK37 is relevant for studies involving phospholipid metabolism, kinase-associated signaling pathways, and membrane biosynthesis regulation.

ChoKα Inhibitor-3, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoK α1 with an IC50 value of 0.66 μM and possesses the capability to induce apoptosis. This compound is utilized in cancer research [1].

ChoKα Inhibitor-5, a sulfur-containing choline kinase inhibitor, effectively inhibits HChoKα1 with an IC50 value of 0.64 μM and induces apoptosis. It is utilized in cancer research [1].

EB-3D is a potent and selective choline kinase alpha 1 (ChoKα1) inhibitor (IC50: 1 μM) with anti-cancer activity.

ChoKα Inhibitor-4 is a bioisosteric agent that effectively inhibits human choline kinase α1 (HChoK α1) with an IC50 of 0.66 μM. It demonstrates both inhibitory and antiproliferative effects on cancer cells, induces apoptosis through the mitochondrial pathway, and diminishes the expression of anti-apoptotic proteins [1].