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By Target- c-Met/HGFR
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Results for "
capmatinib 2hcl
" in TargetMol Product Catalog- Inhibitors & Agonists2
Capmatinib 2HCl
INC-280 2HCl, INCB28060 2HCl
T42601197376-85-4
Capmatinib 2HCl (INC-280 2HCl) is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.Capmatinib 2HCl exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines. As a result, Capmatinib 2HCl potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis in vitro.
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Capmatinib 2HCl.H2O
INCB28060 2HCl.H2O, INC-280 2HCl.H2O, NVP-INC280 2HCl.H2O
T88251865733-40-9
Capmatinib 2HCl.H2O (NVP-INC280 2HCl.H2O) is an orally bioavailable inhibitor of the proto-oncogene c-Met (HGFR)with potential antineoplastic activity.
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