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Results for "
bms 665053
" in TargetMol Product Catalog- Inhibitors & Agonists1
BMS-665053
BMS665053
T268551173435-64-7
BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC50 = 1.0 nM) that inhibits CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC50 = 4.9 nM). It is also efficacious in the Defensive Withdrawal model of anxiety in rats and has low in vivo clearance [Cl = 17 mL min kg, t½ = 7.8 h].
- $1,520
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