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Results for "
ay 9944 dihydrochloride
" in TargetMol Product Catalog- Inhibitors & Agonists1
AY 9944 dihydrochloride
T14362L1245-84-7In house
AY 9944 dihydrochloride is a intermediate.
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T14362366-93-8In house
AY 9944 is a specific cholesterol biosynthesis inhibitor that targets the 7-dehydrocholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM). At high doses, AY 9944 also inhibits sterol Δ7-Δ8 isomerase in cultured embryos, leading to the accumulation of cholest-8-en-3β-ol[1][2][3]. Additionally, AY 9944 causes hypocholesterolemia and accumulation of 7DHC.
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