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By Target- DNA/RNA Synthesis
- HIV Protease(1)
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Results for "
avx-754
" in TargetMol Product Catalog- Inhibitors & Agonists1
Apricitabine
AVX754, SPD754
T14313160707-69-7In house
Apricitabine (SPD754) is a highly selective and orally active HIV-1 reverse transcriptase inhibitor (Ki=0.08 μM), the (-) enantiomer of 2′-deoxy-3′-oxy-4′-thiocytidine (dOTC) . Apricitabine inhibits DNA polymerase α, β and γ with Ki values of 300 μM, 12 μM and 112.25 μM, respectively. Apricitabine has shown good antiretroviral therapeutic efficacy in antiretroviral HIV-infected patients, with good tolerability and low selective resistance.
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