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By Target- PDE
- Endogenous Metabolite(1)
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Results for "
autotaxin, in mouse plasma
" in TargetMol Product Catalog- Inhibitors & Agonists3
- Natural Products1
ONO-8430506 
T387591354805-08-5
ONO-8430506 is an orally available, potent autotaxin (ATX) ENPP2 inhibitor (IC90: 100 nM) that inhibits ATX activity in mouse plasma.
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PAT-048
T164341359983-15-5
PAT-048 is an effective and selective autotaxin inhibitor. PAT-048 reduces dermal fibrosis in vivo. PAT-048 also inhibits IL-6 mRNA expression but displays no effect on autotaxin protein and pulmonary lysophosphatidic acid (LPA) production in the lung fibrosis model. PAT-048 has an IC50 and IC90 of 20 nM and 200 nM for autotaxin in mouse plasma.
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Lysophosphatidylcholine 18:2
PC(18:2 0:0), 1-Linoleoyl-2-Hydroxy-sn-glycero-3-PC, 18:2 0:0-PC, 18:2 lyso-PC, 18:2 LysoPC
T3679122252-07-9
Lysophosphatidylcholine 18:2 is a mouse metabolite functionally related to linoleic acid.18:2 LysoPC is a major component of oxidized low-density lipoproteins (LDLs), and low plasma levels of LPC 18:2 have been associated with metabolic disorders such as impaired glucose tolerance, insulin resistance, type 2 diabetes, and coronary artery disease.1-Linoleoyl 1-Linoleoyl-2-Hydroxy-sn-glycero-3-PC is also a substrate for the generation of lysophosphatidic acid (LPA) from Autotaxin (LysoPLD), which plays an important role in cell motility.
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