apicidin

Apicidin (OSI 2040) is a histone deacetylase (HDAC) inhibitor with antiparasitic and antiproliferative activity. It attenuates memory deficits, inhibits cell growth and proliferation, and induces apoptosis and autophagy by decreasing Abeta load in APP/PS1 mice, making it a valuable tool for leukemia research.

Apicidin D2 (Compound 4) is a fungal metabolite that functions as an AgrA quorum sensing inhibitor. It exhibits antivirulence activity by non-bactericidally inhibiting the activation of methicillin-resistant Staphylococcus aureus (MRSA) Agr, demonstrating potent inhibitory effects on all Agr types. Apicidin D2 is useful for researching MRSA infections.

Apicidin C (Compound 5a) is a cyclic tetrapeptide with reversible inhibition of HDAC, exhibiting antiprotozoal and antimalarial effects. It has an IC50 of 6 nM against Eimeria tenella and is applicable in malaria infection research.