T8480

Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator .

Mcl-1 inhibitor 17 is an effective inhibitor of the Mcl-1 protein. Mcl-1 is a critical anti-apoptotic member of the Bcl-2 family, frequently overexpressed in various malignancies, where it suppresses apoptosis by sequestering pro-apoptotic proteins such as Bak and Bax. Mcl-1 inhibitor 17 functions by competitively binding to the BH3-binding groove of Mcl-1, thereby releasing pro-apoptotic factors and restoring apoptotic sensitivity in cancer cells. This compound is utilized for research into cancer and other diseases associated with Mcl-1 dysregulation.

LNP Lipid-8 (11-A-M), an ionizable lipid, is utilized in lipid nanoparticles (LNP) for siRNA delivery to T cells without ligand targeting. When loaded with GFP siRNA (siGFP), it significantly silences the GFP gene in a mouse model [1].

Pomalidomide-5-C8-NH2 hydrochloride, a Pomalidomide-based cereblon (CRBN) ligand, is instrumental in the recruitment of CRBN protein. This compound can be linked to the protein ligand via a linker to form PROTAC [1].

Antibiofilm Agent-1, as detailed in WO2017011725A1 (compound 17) [1], serves as an antibacterial agent effective against Gram-positive pathogens.

SCD1/5-IN-1 (Compound 10), a selective SCD1/5 inhibitor, is utilized in the research of neurological diseases [1].

Alpha-GalNAc-TEG-N3 is a click chemistry reagent renowned for its high yield, specificity, and simplicity. This reagent exhibits significant potential for facilitating connections among nucleic acids, lipids, proteins, and various molecules, demonstrating its widespread application across numerous research domains [1].

Thalidomide-5-NH-PEG1-NH2 hydrochloride is a Thalidomide-based cereblon ligand designed for CRBN protein recruitment. It facilitates the formation of PROTAC molecules by linking to target protein ligands, such as THAL-SNS-032, via a connector.

Thalidomide-5-NH-PEG2-NH2 hydrochloride is a cereblon ligand based on Thalidomide, designed to recruit CRBN proteins. It has the capability to be linked with target protein ligands via a linker, facilitating the formation of PROTAC molecules, such as THAL-SNS-032.

Thalidomide-5-NH-PEG3-NH2 hydrochloride is a cereblon ligand based on Thalidomide that targets CRBN proteins. It utilizes a linker to attach to a target protein ligand, facilitating the formation of a PROTAC molecule, such as THAL-SNS-032.