T8153

glycohyodeoxycholic acid is a major metabolite of the secondary bile acid hyodeoxycholic acid in humans.

Pegacaristim, a monoclonal antibody, exhibits thrombopoietic activity by promoting the generation of platelets [1] [2].

PDE5-IN-11 is a potent PDE5 inhibitor with an IC50 of 40 nM and displays inhibitory activity against PDE4 and PDE6 with IC50 values of 1.78 μM and 0.09 μM, respectively [1].

PDE11A4-IN-1 (compound 23b) is a potent, selective inhibitor of PDE11A4 with an IC50 of 12 nM, demonstrating high selectivity against PDE1, PDE2, PDE7, PDE8, and PDE9 [1].

PCSK9-IN-20 (Compound 3i) is a PCSK9 inhibitor with an IC50 value of 3.96 µM, which reduces PCSK9 and enhances LDLR protein levels in vitro [1].

PB089 is a drug-like molecule featuring a polyethylene glycol (PEG) unit and a cleavable linker connected to Exatecan [1].

Paucimannose, a prevalent mannosidic N-glycoepitope found in invertebrates and plants, is also expressed in cancers [1].

PAT1inh-B01, a selective SLC26A6 inhibitor, impedes PAT1 (a Cl-/HCO3- exchanger) activity, with an IC50 of 350 nM, effectively inhibiting anion exchange. It also obstructs fluid absorption in the small intestine and is utilized in the study of small intestinal hyposecretory disorders [1].