T7440

p,p'-DDE (p,p'-dichlorodiphenyldichloroethylene) is a metabolite and degradation product of the organochlorine pesticide DDT

TC113, a Gemcitabine (GEM)-based conjugate incorporating the c(RGDyK) sequence, is internalized by A549 cells via the integrin αvβ3 pathway. It demonstrates significant antiproliferative effects on both WM266.4 and A549 cell lines.

FAP-PI3KI1, a fibroblast-activated protein (FAP)-targeted PI3K inhibitor, selectively targets FAP-expressing human idiopathic pulmonary fibrosis (IPF) cells. It effectively inhibits collagen synthesis and reduces collagen deposition [1].

NS5A-IN-1 is a proagent of the HCV NS5A inhibitor, Pibrentasvir (ABT-530).

Ent-Heronamide C possesses antifungal properties and is utilized as a probe for analyzing the mode of action of heronamide C [1].

PEG2000-C-DMG, a pegylated lipid, facilitates the creation of Onpattro, a hepatically targeted investigational RNAi therapeutic that effectively decreases the synthesis of both mutant and wild-type transthyretin by precisely targeting the 3′ untranslated region of transthyretin mRNA [1] [2].

BRD2889, an analog of the alkaloid piperlongumine, serves as a potent modulator of the GSTP1-ISCU axis in pulmonary hypertension (PH) [1].

EVT-401 (P2X7 receptor antagonist-1), a purinergic P2X7 receptor antagonist, demonstrates efficacy in combating neuroinflammation [1].