T7176

Pitolisant hydrochloride (Ciproxidine) is a potent and selective inverse agonist of the histamine H3 receptor(Ki : 0.16 nM).

4-Chlorokynurenine is a prodrug of 7-Cl-kynurenic acid (7-Cl-KYNA), a potent, selective antagonist of the NMDA/glycine receptor.

2-(4-chlorophenyl)quinazolin-4-ol is an effective inhibitor of β-glucuronidase (IC₅₀ = 39.8 µM), and can be used in the study of glucuronidase-related diseases.

WX2-43 is a PRMT5-KLF4 inhibitor. Biotin-labeled WX2-43 binds to GST-PRMT5 with a dissociation constant Kd of 11.0 nM. It binds to the L400 to M500 amino acid region of PRMT5 protein, effectively blocking the interaction between KLF4 and PRMT5 and inhibiting KLF4 methylation modification. Functionally, WX2-43 downregulates p21 expression and upregulates Bax level, thereby suppressing the progression of triple-negative breast tumors. It can be applied to mechanism research of triple-negative breast cancer and colorectal cancer.

Pitolisant-D6 hydrochloride is a deuterated compound of Pitolisant Hydrochloride (T7176). Pitolisant hydrochloride has a CAS number of 903576-44-3. Pitolisant hydrochloride is a potent and selective inverse agonist of the histamine H3 receptor (Ki : 0.16 nM).