T6252

Ipatasertib (GDC-0068) is a selective, ATP-competitive pan-Akt inhibitor that inhibits Akt1 (IC50:5 nM), Akt2 (IC50:18 nM), and Akt3 (IC50:8 nM). Ipatasertib (GDC-0068) can lead to p53-independent PUMA activation by inhibiting Akt, thereby activating FoxO3a and NF-κB simultaneously, directly binding to the PUMA promoter, upregulating PUMA transcription and Bax-mediated intrinsic mitochondrial apoptosis.

TP-16 is a novel potent and selective EP4 antagonist that blocks the function of IMCs and enhances cytotoxic T cell-mediated tumor elimination in vivo.

Imidocarb dihydrochloride monohydrate is an effective antiprotozoal agent against the parasite B. bovis (IC50: 87 μg/ml).

A2AAR/HDAC-IN-1 (compound 14c) is an orally active, balanced dual inhibitor of A2AAR (Ki: 163.5 nM) and HDAC1 (IC50: 145.3 nM).

FGFR-IN-4 is a potent inhibitor of FGFR with potential applications in cancer disease studies.

Anticancer agent 40 (compound 3e) is a potent anticancer agent with effects on SKBR-3 cells (IC50: 0.94 nM), SKOV-3 cells (IC50: 0.98 nM), PC-3 cells (IC50: 0.96 nM), U-87 cells (IC50: 0.95 nM), and HDF cells (IC50: 2.13 nM).

Panobinostat lactate is a potent, orally active, non-selective HDAC inhibitor with antitumor effects. Panobinostat lactate can be used to study refractory or relapsed multiple myeloma.

HIV-1 inhibitor-8 is a potent, orally active, low toxicity HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI). HIV-1 inhibitor-8 is capable of acting on WT HIV-1 reverse transcriptase (IC50: 0.081 μM). HIV-1 inhibitor-8 exhibited potent antiviral effects against various HIV-1 strains with EC50 values of 4.44-54.5 nM.

INO-1001 is a potent, selective poly(ADP-ribose) polymerase (PARP) inhibitor with antitumor activity.INO-1001 is a potent radiosensitization enhancer that uses interference with DNA repair mechanisms to enhance radiation-induced cell killing and necrotic cell death.

Dopamine D3 receptor ligand is a potent, selective, high-affinity compound with 89 times greater selectivity for D3 receptors (Ki: 8 nM) compared to D2 receptors (Ki: 715 nM).