T6234

Ambroxol hydrochloride (Mucosolvan) is a metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.

NBD-14189 is a potent HIV-1 entry antagonist that acts against the HIV-1HXB2 pseudovirus (IC50: 89 nM). NBD-14189 binds to HIV-1 gp120 and exhibits a strong antiviral effect (EC50 < 200 nM).

(R)-Larotrectinib is a potent TRK inhibitor, targeting TrkA with an IC50 value of 28.5 nM. (R)-Larotrectinib can be utilized to study cancer, inflammation, and certain infectious diseases.

CSF1R-IN-4 is a potent CSF-1R inhibitor that can modulate the exchange of inflammatory factors between TAM and glioma cells, presenting potential for cancer research [EGFR-IN-40].

EGFR-IN-40 (compound 3z) is a potent inhibitor of BTK (IC50: 1.2 nM), EGFR (IC50: 5.3 nM), and ITK (IC50: 46.1 nM).

Neuraminidase-IN-4 (Compound 4b) is a potent inhibitor of neuraminidase (EC50: 1.59 μM) and exhibits significant antiviral activity against A/chicken/Hubei/327/2004 (H5N1-DW).

MPO-IN-5 is a potent, irreversible inhibitor of MPO (myeloperoxidase). MPO-IN-5 inhibits MPO peroxidation (IC50: 0.22 μM) and hERG binding (IC50: 2.8 μM). 23000 M 1s 1.

A1AR antagonist 3 (compound 13) is a selective adenylate 1 (A1) receptor antagonist with an affinity for human A1 (Ki: 9.69 nM) and rat A1 (Ki: 0.529 nM). It is suitable for research on neurological diseases.

Tubulin polymerization-IN-8 (compound IIc) is a potent inhibitor of tubulin polymerization, inducing concentration-dependent cell cycle arrest at the G2/M phase in HCT116 tumor cells and significantly inhibiting tubulin polymerization with an IC50 of 12.7 μM, showing potential for cancer research [1].