T6232

Vilazodone Hydrochloride (EMD 68843) , a partial agonist of 5-HT1A receptors and specific serotonin reuptake inhibitor (SSRI), is utilized in treating of the major depressive disorder.

Darifenacin (UK-88525) is a muscarinic receptor M3 antagonist with anticonvulsant activity and can be used to study urinary incontinence and overactive bladder.

ST247 is a potent PPARβ/δ inverse agonist with a high affinity for PPARβ/δ and is able to inversely regulate the expression of the activation marker CCL2. ST247 inhibits agonist-induced transcriptional activity of PPARβ/δ. ST247 efficiently induces interaction with co-repressors.

(S)-MALT1-IN-5 is a potent inhibitor of MALT1 protease, capable of inhibiting MALT1 activity and potentially mitigating the enhancement of MALT1 activity due to abnormal T-cell or B-cell receptor signaling, cancer, or inflammatory diseases. It has potential for studies related to MALT1-related diseases.

MALT1-IN-5 is a potent inhibitor of the MALT1 protease and can be used in cancer research.

Flibanserin (BIMT-17; BIMT-17BS) hydrochloride is an orally active compound that functions as a 5-HT1A receptor agonist (Ki: 1 nM) and a 5-HT2A receptor antagonist (Ki: 49 nM) of 5-hydroxytryptamine. It possesses antidepressant and anxiolytic effects and is used in studies of hypoactive sexual desire (HSDD).

CXCR7 antagonist-1 hydrochloride is a CXCR7 antagonist that inhibits binding of SDF-1 chemokine (CXCL12 chemokine) or I-TAC to CXCR7, applicable for tumor and inflammation research.

NUCC-0223619 is an IDO1 inhibitor that induces the degradation of IDO protein and can be involved in the synthesis of PROTAC.

HDAC2-IN-1 (Compound 17) is an orally active, competitive HDAC2 inhibitor (IC50: 0.5 μM) that crosses the blood-brain barrier and also inhibits HDAC1 (IC50: 1.61 μM) and HDAC8 (IC50: 0.98 μM).

Cabotegravir sodium (GSK-1265744) is an orally active, membrane-permeable HIV integrase inhibitor (IC₅₀ = 2.5 μM) and also an OAT1/OAT3 inhibitor (IC₅₀ = 0.81/0.41 μM). It inhibits HIV replication and may be used in AIDS research.