T6097

GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).

TL8-506 is a selective and potent TLR8 agonist that induces cytokine and chemokine production.TL8-506 alleviates inflammation and autoimmune diseases.

Caprochlorone exhibits antiviral activity against orthopoxvirus that decreases the influenza virus titers in infected-mice lungs. Caprochlorone can inhibit cell penetration by virus as well as delays newly formed virus release from the cell [1] [2] [3].

Antitubercular agent-14 (Compound 1) exhibits antitubercular activity with an MIC value of 0.3 μg/mL against M. tuberculosis [1].

Pim-1 kinase inhibitor 1 can be used in cancer research, showing anticancer activity against a variety of cancer cell lines by promoting cell apoptosis. Pim-1 kinase inhibitor 1 is an inhibitor of Pim-1 kinase with an IC 50 value of 0.11 μM [1].

HPK1-IN-24 (example 51) is a hematopoietic progenitor kinase 1 (HPK1) inhibitor (Ki = 100 nM) with potential applications in cancer research [1].

Antitumor agent-50 (compound 1a) is a thiazolidinone. Antitumor agent-50 is an effective antitumor agent that has the potential for the research of osteosarcoma (OS) [1].

Bezuclastinib (CGT9486) is a novel, potent and highly selective tyrosine kinase and c-kit D816V inhibitor for the study of advanced mastocytosis.

COX-2-IN-7 (compound 4a) is a potent and selective COX-2 inhibitor with greater selectivity than Celecoxib and an IC50 value of 6.585 µM. It exhibits good anti-inflammatory properties and low ulcerogenic activity in vivo[1].

Oxaprozin potassium is an orally active and potent inhibitor of COX, with IC50 values of 2.2 μM for human platelet COX-1 and 36 μM for IL-1-stimulated human synovial cell COX-2. It induces cell apoptosis and inhibits NF-κB activation. The inhibition of the Akt/IKK/NF-κB pathway by oxaprozin potassium contributes to its anti-inflammatory properties [1] [2].